Marker of myofibroblast antibody-α-SMA/ACTA2 Monoclonal Antibody

ACTA2 (actin alpha 2) is an actin protein
with several aliases including alpha-actin, alpha-actin-2, aortic smooth muscle
or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA). Actins are
a family of globular multi-functional proteins that form microfilaments. ACTA2
is one of 6 different actin isoforms and is involved in the contractile
apparatus of smooth muscle. ACTA2 (as with all the actins) is extremely highly
conserved and found in nearly all mammals.

In humans, ACTA2 is encoded by the ACTA2
gene located on 10q22-q24. Mutations in this gene cause a variety of vascular
diseases, such as thoracic aortic disease, coronary artery disease, stroke,
Moyamoya disease, and multisystemic smooth muscle dysfunction syndrome.

ACTA2 (commonly referred to as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation.

Figure: Diverse origins of the
myofibroblast—implications for kidney fibrosis (From Nature Reviews)

Abbkine α-SMA Monoclonal Antibody Helps Basic Cancer Research! Basic information about the product:

Product name	#CAT	Reactivity	Applications	Dilution ratio	Observed Band(KD)
α-SMA Monoclonal Antibody	ABM0052	Human/Mouse/ Rat	WB/IF/IHC-P	WB (1:10000-1:100000) IF (1:100-1:200) IHC-P (1:1000-1:2000)	42KD

Abbkine α-SMA Monoclonal Antibody verification results:

	Western blot analysis of 1) Hela, 2) 3T3, 3) rat brain using α-SMA Monoclonal Antibody.
	Immunofluorescence analysis of human liver tissue.
	Immunohistochemical analysis of paraffin-embedded mouse liver tissue