Transthyretin (TTR) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid. More than 80 different mutations in TTR have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.Abbkine TTR Mouse Monoclonal Antibody(1D7) was affinity-purified from mouse ascites by affinity-chromatography using TTR recombinant protein antigen. This antibody could be applied to IF, IHC-p, WB, which has been validated. This antibody can react with Human samples. Optimal working dilutions should be determined experimentally by researchers. Abbkine suggest that the starting dilutions are: WB: 1:500-2000, IHC-p: 1:50-2000.
There are a lot of antibody brands in the market, it maybe a little difficult for a beginner to choose an appropriate antibody for his experiment. Hope my experience could help you. I used many antibodies from different firms. Through the comparison, and I think Abbkine is a good selection, which has high quality with lower price, as well as perfect protein specificity and strong technical support. Abbkine provide the primary antibodies that involve many fields. I bought some antibodies to do IHC experiments, including TTR Mouse Monoclonal Antibody(1D7), and they both make good performances. You could save the costs along with satisfactory results.
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